Searchable abstracts of presentations at key conferences in endocrinology

ea0009oc32 | Oral Communication 4: Steroids | BES2005

Differential induction of fibroblast 11beta-HSD1: a mechanism for tissue-specific regulation of inflammation

Hardy R , Cooper M , Filer A , Parsonage G , Buckley C , Stewart P , Hewison M

Acute inflammation plays an important role in the normal immune system by helping to coordinate host responses to danger signals such as infection. In most cases the inflammation is rapidly resolved but in chronic inflammatory diseases such as rheumatoid arthritis (RA) the inflammation persists leading to localized accumulation of potentially damaging immune cells. It remains unclear why inflammation persists in some tissues and not in others. Recent studies have shown that st...